Investigating the molecular mechanisms of neural circuit assembly
- Role of Adhesion G-protein coupled receptors -
The remarkable specificity of neuronal wiring in the developing brain is controlled in its final stage by cell adhesion molecules at the synapse that bridges the pre- and postsynaptic neuron. Our laboratory is currently focused on a group of enigmatic cell-adhesion molecules known as Adhesion G-protein coupled receptors (Adhesion-GPCRs), and the role they play in synaptic assembly and specification processes. Combining genetic engineering approaches with viral, electrophysiological, and microscopy methodology, our work is focused on understanding synaptic patterning specificity during brain development.